SKAT R-package
SKAT is an R-package for gene/region-based multiple variant tests. It has functions for Burden test, SKAT, and SKAT-O with adjusting for covariates and kinship.
Main Functions and key references
Following are main functions and key references. For details, please refer the package manual and vignettes.
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SKAT function: Burden test, SKAT, and SKAT-O
- Lee, S., Emond, M.J., ..., and Lin, X. (2012). Optimal unified approach for rare variant association testing with application to small sample case-control whole-exome sequencing studies. AJHG, 91, 224-237.
- Lee, S., Wu, M. and Lin, X. (2012). Optimal tests for rare variant effects in sequencing association studies. Biostatistics, 13, 762-775
- Wu, M., Lee, S., Cai, T., Li, Y., Boehnke, M. and Lin, X. (2011). Rare Variant Association Testing for Sequencing Data Using the Sequence Kernel Association Test (SKAT). AJHG, 89, 82-93.
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Robust approaches functions for binary traits: SKATBinary_Robust and SKAT_CommonRare_Robust
- Zhao, Z., Bi, W., Zhou, W., VanderHaar, P., Fritsche, L.G., Lee, S. (2020) UK Biobank Whole-Exome Sequence Binary Phenome Analysis with Robust Region-based Rare-Variant Test. AJHG, 2020, 3-12.
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SKATBinary function: Burden test, SKAT, and SKAT-O with efficient resampling for binary traits
- Lee, S., Fuchsberger, C., Kim, S., Scott, L. (2016) An efficient resampling method for calibrating single and gene-based rare variant association analysis in case-control studies, Biostatistics, 17, 1-15.
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SKAT_CommonRare function: joint test for common and rare variants
- Ionita-Laza, I., Lee, S., Makarov, V., Buxbaum, J. Lin, X. (2013). Sequence kernel association tests for the combined effect of rare and common variants. AJHG, 92, 841-853.
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SKAT_ChrX function: X-chromosome test
- Ma, C., Boehnke, M., Lee, S. and the GoT2D investigators (2015) Evaluating the calibration and power of three gene-based association tests for the X chromosome, Genetic Epidemiology, 39, 499-508.
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SKAT_NULL_emmaX function: Kinship adjustment
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SSD functions: plink binary file related functions
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Power_Continuous, ...: power calculation functions