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hemberg-lab / D3E

Licence: GPL-3.0 license
Discrete Distributional Differential Expression

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D3E: Discrete Distributional Differential Expression

About

D3E is a tool for identifying differentially-expressed genes, based on single-cell RNA-seq data. D3E consists of two modules: one for identifying differentially expressed (DE) genes, and one for fitting the parameters of a Poisson-Beta distribution. A web-version which can be used for small samples can be accessed at http://www.sanger.ac.uk/sanger/GeneRegulation_D3E/

Files

  • D3EUtil.py : a collection of methods for running the D3E analysis
  • D3ECmd.py : an actual D3E tool (requires D3EUtil.py for execution)
  • D3EWed.py : a light version of D3E, for running as a web-service (requires D3EUtil.py for execution)
  • D3EMakeControl : a script for making a control file for the analysis
  • D3EAnalyse : a script for filtering DE genes based on the result of control file analysis

Getting Started

Please visit our Wiki pages for User Guide and Example.

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